The Centre for Evidence in Transplantation
The Centre for Evidence in Transplantation (CET) (www.transplantevidence.com) was established at the beginning of 2005 by Professor Sir Peter Morris with the aim of providing a source of high quality evidence-based information on all aspects of solid organ transplantation. The Centre is devoted to evaluating the quality of evidence in organ transplantation (kidney, heart, lung, pancreas, liver, etc.) and defines gaps in our knowledge in these different areas. The CET is based within the Nuffield Department of Surgical Sciences and the Oxford Transplant Centre.
The CET has been involved in a number of projects since its establishment, one of which is the development and maintenance of the Transplant Library (www.transplantlibrary.com). The Transplant Library is an electronic library of all randomised controlled trials (RCTs) in solid organ transplantation, including congress abstracts, from 1970 to the present and more recently includes systematic reviews that are regarded as of reasonable quality, and clinical practice guidelines. We have also added invited expert commentaries to key articles and the ability for users to comment on and discuss articles on the site. Since March 2020 the Library includes published evidence and other information, such as webinars, on COVID-19 in solid organ transplantation.
To promote the Transplant Library CET produces the Transplant Trial Watch, a monthly overview of RCTs that were recently added to the Transplant Library. The Trial Watch includes a summary of the RCT, critical commentary written by CET and critical appraisal.
The Centre has also carried out and is carrying out a large number of systematic reviews and meta-analyses in all aspects of solid organ transplantation. Many of these have been published in peer reviewed journals and are well cited. The CET staff have expertise in literature searching, risk of bias assessment and meta-analysis, including handling missing data, mixed effects analysis and network meta-analysis.
More recently, the CET has been involved in the design and reporting of clinical trials in transplantation, including the management and design of the Consortium for Organ Preservation in Europe (COPE) clinical trials in partnership with the Surgical Interventional Trials Unit (SITU).
The CET also has an agreement with the European Society for Organ Transplantation (ESOT) and provides research support to the society, and its members and scientific working groups.
www.nds.ox.ac.uk/research/centre-for-evidence-in-transplantation